Letting the breaks off MYCN
نویسندگان
چکیده
منابع مشابه
Letting people off the hook: when do good deeds excuse transgressions?
Three studies examined when and why an actor's prior good deeds make observers more willing to excuse--or license--his or her subsequent, morally dubious behavior. In a pilot study, actors' good deeds made participants more forgiving of the actors' subsequent transgressions. In Study 1, participants only licensed blatant transgressions that were in a different domain than actors' good deeds; bl...
متن کاملThe MYCN enigma: significance of MYCN expression in neuroblastoma.
MYCN amplification strongly predicts adverse outcome of neuroblastoma. However, the significance of MYCN expression in the clinical and biological behavior of neuroblastoma has been unclear. To address this question, we first examined the expression of MYCN in combination with TrkA (a favorable prognostic indicator of neuroblastoma) in 91 primary neuroblastoma by quantitative reverse transcript...
متن کاملMYCN and the epigenome
It is well known that Neuroblastoma (NB) patients whose tumors have an undifferentiated histology and a transcriptome enriched in cell cycle genes have a worse prognosis. This contrasts with the good prognoses of patients whose tumors have histologic evidence of differentiation and a transcriptome enriched in differentiation genes. Tumor cell lines from poor prognosis, high-risk patients contai...
متن کاملThe MYCN Oncogene
MYCN is a member of the MYC family of oncogenes, which also includes c-MYC and MYCL. Despite knowing about the existence of MYCN for nearly thirty years, the majority of functional studies involving MYC family members have focused on c-MYC due to the limited expression profile of MYCN in human cancers, and also in part due to the existence of highly conserved functional domains between c-MYC an...
متن کاملLetting my daughter go.
I always knew Daisy would die before reaching adulthood. She was my fourth child, born prematurely in December 2004 with a severe form of rare genetic condition called Costello syndrome. Daisy required complex care, but every decision about her care was made on the basis of improving the quality of her life, which meant helping her do the things she loved, such as being at home with her family,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2016
ISSN: 1350-9047,1476-5403
DOI: 10.1038/cdd.2016.112